PLRX Stock — Pliant Therapeutics Inc

Pliant Therapeutics Inc (PLRX)

Updated October 16, 2026.

PLRX is a Stock. Total return is -95.8% over the past 6.4 years, 263.1 points behind SPY at 167.3%.

Pliant Therapeutics is a clinical-stage biopharmaceutical company developing integrin-based therapies for solid tumors, with its lead candidate PLN-101095 currently in early-stage human trials and a proprietary platform of over 15,000 integrin binding molecules in its pipeline. The company does not currently distribute to shareholders. This security appeals to investors seeking exposure to early-stage biotech development with conviction in integrin-targeted drug approaches, though investors should be aware that clinical-stage companies carry substantial development and regulatory risk.

PLRX performance versus SPY

Price and return data through 2026-10-16.

Total return is -95.8% over the past 6.4 years, 263.1 points behind SPY at 167.3%. Over the past year its total return — price change plus distributions reinvested — is -45.5%. Its deepest 1-year drawdown was 52.7%.

PLRX key facts

Asset type

Stock

Asset class

Equity

Inception date

06/03/2020

Distribution frequency

None

Last close

$0.90 (as of 2026-10-16)

Market cap

$55,723,515

Average volume

582309.0

Beta

1.28

Payout ratio

0.0%

EPS

$-1.50

How Dividend Vision calculates yield and returns

Distribution rate (the posted rate) uses calculation basis unavailable. Issuer rates can use a different denominator and date, including ex-date NAV. Trailing-12-month yield is the sum of split-adjusted cash distributions with ex-dates in the last 12 months, divided by the published price. It lags a recent raise or cut. Total return uses split-adjusted close with distributions reinvested on the ex-dividend date (a modeling convention, not the cash-settlement date) from the first stored bar on or after inception through the latest bar, compared with the same window on the benchmark. That is the security's total return, not your personal gain/loss.

Yield and safety methodology · Distribution rate methodology · Distribution Safety Score methodology

Sources and review

Primary sources: prices and distributions from Dividend Vision, derived from vendor EOD data.

Reviewed by Bert Sweet, CEO and Co-owner of Dividend Vision. Methodology: Distribution Safety Score.

PLRX risks and drawbacks

Total return has trailed SPY over the available window. The deepest 1-year drawdown on record here is 52.7%.

Who may consider PLRX — and who may not

It is a weaker fit for investors who need monthly cash flow (PLRX does not currently distribute); investors whose main goal is matching SPY total return. This is educational context, not a recommendation to buy or sell.

More on PLRX

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Tagged: Healthcare.

Frequently asked questions