PRME Stock — Prime Medicine, Inc. Common Stock

Prime Medicine, Inc. Common Stock (PRME)

Updated October 16, 2026.

PRME is a Stock. Total return is -77.4% over the past 4 years, 197.4 points behind SPY at 120.0%.

Prime Medicine is a biotechnology company developing genetic medicines using gene editing technology to treat diseases including Chronic Granulomatous Disease, Wilson Disease, and Alpha-1 Antitrypsin Deficiency, with its lead candidate in Phase 1/2 clinical trials. The company does not currently distribute dividends. This security may appeal to growth-oriented investors seeking exposure to early-stage biotechnology development, though it carries the risk profile typical of clinical-stage companies.

PRME performance versus SPY

Price and return data through 2026-10-16.

Total return is -77.4% over the past 4 years, 197.4 points behind SPY at 120.0%. Over the past year its total return — price change plus distributions reinvested — is -40.2%. Its deepest 1-year drawdown was 56.3%.

PRME key facts

Asset type

Stock

Asset class

Equity

Inception date

10/20/2022

Distribution frequency

None

Last close

$3.47 (as of 2026-10-16)

Market cap

$629,377,690

Average volume

4383228.0

Beta

2.377

Payout ratio

0.0%

EPS

$-1.07

How Dividend Vision calculates yield and returns

Distribution rate (the posted rate) uses calculation basis unavailable. Issuer rates can use a different denominator and date, including ex-date NAV. Trailing-12-month yield is the sum of split-adjusted cash distributions with ex-dates in the last 12 months, divided by the published price. It lags a recent raise or cut. Total return uses split-adjusted close with distributions reinvested on the ex-dividend date (a modeling convention, not the cash-settlement date) from the first stored bar on or after inception through the latest bar, compared with the same window on the benchmark. That is the security's total return, not your personal gain/loss.

Yield and safety methodology · Distribution rate methodology · Distribution Safety Score methodology

Sources and review

Primary sources: prices and distributions from Dividend Vision, derived from vendor EOD data.

Reviewed by Bert Sweet, CEO and Co-owner of Dividend Vision. Methodology: Distribution Safety Score.

PRME risks and drawbacks

Total return has trailed SPY over the available window. The deepest 1-year drawdown on record here is 56.3%.

Who may consider PRME — and who may not

It is a weaker fit for investors who need monthly cash flow (PRME does not currently distribute); investors whose main goal is matching SPY total return. This is educational context, not a recommendation to buy or sell.

More on PRME

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Tagged: Healthcare.

Frequently asked questions