SION Stock — Sionna Therapeutics, Inc.

Sionna Therapeutics, Inc. (SION)

Updated October 16, 2026.

SION is a Stock. Total return is -78.4% over the past 1.7 years, 106.8 points behind SPY at 28.4%.

Sionna Therapeutics is a clinical-stage biopharmaceutical company developing medicines for cystic fibrosis treatment, with a pipeline including multiple CFTR correctors and potentiators in Phase 1 and Phase 2 trials. As an early-stage biotech company, it does not currently distribute income to shareholders. This security appeals primarily to investors with high risk tolerance seeking exposure to clinical-stage drug development rather than those focused on dividend income.

SION performance versus SPY

Price and return data through 2026-10-16.

Total return is -78.4% over the past 1.7 years, 106.8 points behind SPY at 28.4%. Over the past year its total return — price change plus distributions reinvested — is -88.1%. Its deepest 1-year drawdown was 92.4%.

SION key facts

Asset type

Stock

Asset class

Equity

Inception date

02/06/2025

Distribution frequency

None

Last close

$3.89 (as of 2026-10-16)

Market cap

$175,634,784

Average volume

1483533.0

Payout ratio

0.0%

EPS

$-2.20

How Dividend Vision calculates yield and returns

Distribution rate (the posted rate) uses calculation basis unavailable. Issuer rates can use a different denominator and date, including ex-date NAV. Trailing-12-month yield is the sum of split-adjusted cash distributions with ex-dates in the last 12 months, divided by the published price. It lags a recent raise or cut. Total return uses split-adjusted close with distributions reinvested on the ex-dividend date (a modeling convention, not the cash-settlement date) from the first stored bar on or after inception through the latest bar, compared with the same window on the benchmark. That is the security's total return, not your personal gain/loss.

Yield and safety methodology · Distribution rate methodology · Distribution Safety Score methodology

Sources and review

Primary sources: prices and distributions from Dividend Vision, derived from vendor EOD data.

Reviewed by Bert Sweet, CEO and Co-owner of Dividend Vision. Methodology: Distribution Safety Score.

SION risks and drawbacks

Total return has trailed SPY over the available window. The deepest 1-year drawdown on record here is 92.4%.

Who may consider SION — and who may not

It is a weaker fit for investors who need monthly cash flow (SION does not currently distribute); investors whose main goal is matching SPY total return. This is educational context, not a recommendation to buy or sell.

More on SION

• All tickers starting with S

Tagged: Healthcare.

Frequently asked questions