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SPRO Stock — Spero Therapeutics Inc
Spero Therapeutics Inc (SPRO)
Updated October 16, 2026.
SPRO is a Stock. Total return is -90.4% over the past 9 years, 330.5 points behind SPY at 240.1%.
Spero Therapeutics is a clinical-stage biopharmaceutical company developing novel treatments for multi-drug resistant bacterial infections and rare diseases, with its lead candidate being an oral carbapenem-class antibiotic in development for complicated urinary tract infections. The company does not currently have an established distribution schedule. This security may appeal to investors with a high risk tolerance who are interested in early-stage biotech exposure.
SPRO performance versus SPY
Price and return data through 2026-10-16.
Total return is -90.4% over the past 9 years, 330.5 points behind SPY at 240.1%. Over the past year its total return — price change plus distributions reinvested — is -53.2%. Its deepest 1-year drawdown was 63.1%.
| Window | Total return | CAGR |
|---|---|---|
| 1M | -0.9% | — |
| 3M | -29.9% | — |
| 6M | -59.0% | — |
| YTD | -52.8% | — |
| 1Y | -53.2% | — |
| 2Y CAGR | — | -5.80% |
| 3Y CAGR | — | -1.20% |
| 5Y CAGR | — | -42.20% |
| Since inception (9 years) | -90.4% | -23.10% |
SPRO key facts
- Asset type
- Stock
- Asset class
- Equity
- Inception date
- 11/02/2017
- Distribution frequency
- None
- Last close
- $1.10 (as of 2026-10-16)
- Market cap
- $64,058,310
- Average volume
- 361227.0
- Beta
- 1.498
- Payout ratio
- 0.0%
- P/E ratio
- 8.46
- EPS
- $0.13
How Dividend Vision calculates yield and returns
Distribution rate (the posted rate) uses calculation basis unavailable. Issuer rates can use a different denominator and date, including ex-date NAV. Trailing-12-month yield is the sum of split-adjusted cash distributions with ex-dates in the last 12 months, divided by the published price. It lags a recent raise or cut. Total return uses split-adjusted close with distributions reinvested on the ex-dividend date (a modeling convention, not the cash-settlement date) from the first stored bar on or after inception through the latest bar, compared with the same window on the benchmark. That is the security's total return, not your personal gain/loss.
Yield and safety methodology · Distribution rate methodology · Distribution Safety Score methodology
Sources and review
Primary sources: prices and distributions from Dividend Vision, derived from vendor EOD data.
Reviewed by Bert Sweet, CEO and Co-owner of Dividend Vision. Methodology: Distribution Safety Score.
SPRO risks and drawbacks
Total return has trailed SPY over the available window. The deepest 1-year drawdown on record here is 63.1%.
Who may consider SPRO — and who may not
It is a weaker fit for investors who need monthly cash flow (SPRO does not currently distribute); investors whose main goal is matching SPY total return. This is educational context, not a recommendation to buy or sell.
More on SPRO
Frequently asked questions
Does SPRO pay monthly?
No. SPRO does not currently distribute.
When does SPRO pay a dividend?
SPRO does not currently distribute.
How has SPRO performed?
Total return is -90.4% over the past 9 years, 330.5 points behind SPY at 240.1%. Over the past year its total return — price change plus distributions reinvested — is -53.2%. Its deepest 1-year drawdown was 63.1%.
Tickers
Holdings as-of date unavailable.
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