TLPH Stock — Talphera Inc.

Talphera Inc. (TLPH)

Updated October 16, 2026.

TLPH is a Stock. Total return is -98.8% over the past 15.7 years, 754.2 points behind SPY at 655.4%.

Talphera is a specialty pharmaceutical company developing therapies for use in medically supervised settings, including Niyad, a regional anticoagulant for extracorporeal circuits, and LTX-608, a nafamostat formulation being studied for conditions including disseminated intravascular coagulation and acute respiratory distress syndrome, along with pre-filled syringe products containing ephedrine and phenylephrine. The company does not currently distribute dividends. This security may appeal to those seeking exposure to early-stage pharmaceutical development.

TLPH performance versus SPY

Price and return data through 2026-10-16.

Total return is -98.8% over the past 15.7 years, 754.2 points behind SPY at 655.4%. Over the past year its total return — price change plus distributions reinvested — is -6.9%. Its deepest 1-year drawdown was 50.5%.

TLPH key facts

Asset type

Stock

Asset class

Equity

Inception date

02/11/2011

Distribution frequency

None

Last close

$1.08 (as of 2026-10-16)

Market cap

$56,058,260

Average volume

41440.0

Beta

0.675

Payout ratio

0.0%

Forward P/E

1.0172

EPS

$-0.26

How Dividend Vision calculates yield and returns

Distribution rate (the posted rate) uses calculation basis unavailable. Issuer rates can use a different denominator and date, including ex-date NAV. Trailing-12-month yield is the sum of split-adjusted cash distributions with ex-dates in the last 12 months, divided by the published price. It lags a recent raise or cut. Total return uses split-adjusted close with distributions reinvested on the ex-dividend date (a modeling convention, not the cash-settlement date) from the first stored bar on or after inception through the latest bar, compared with the same window on the benchmark. That is the security's total return, not your personal gain/loss.

Yield and safety methodology · Distribution rate methodology · Distribution Safety Score methodology

Sources and review

Primary sources: prices and distributions from Dividend Vision, derived from vendor EOD data.

Reviewed by Bert Sweet, CEO and Co-owner of Dividend Vision. Methodology: Distribution Safety Score.

TLPH risks and drawbacks

Total return has trailed SPY over the available window. The deepest 1-year drawdown on record here is 50.5%.

Who may consider TLPH — and who may not

It is a weaker fit for investors who need monthly cash flow (TLPH does not currently distribute); investors whose main goal is matching SPY total return. This is educational context, not a recommendation to buy or sell.

More on TLPH

• All tickers starting with T

Tagged: Healthcare.

Frequently asked questions